NOX1

Across TCGA pan-cancer cohorts, NOX1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NOX1 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher NOX1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NOX1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

STAD, CESC, and UCEC are the cancer types where NOX1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	III,IV	0.157	0.638	<.001	42	view →
CESC	OS	Median	III,IV	0.095	0.755	<.001	18	view →
UCEC	DFS	Median	All	0.953	0.611	.004	18	view →
HNSC	OS	Median	All	0.151	0.685	.007	3	view →
LIHC	OS	Median	III,IV	0.270	0.732	.021	3	view →
SKCM	OS	Median	All	0.884	0.298	.013	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NOX1–STAD (OS)

Open the STAD breakdown →