NOVA2

Across TCGA patient cohorts, NOVA2 protein abundance is significantly associated with the RNA expression of many other genes, with 18,224 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NOVA2-associated genes across cancer lineages are EDNRB, CD34, and RGS5. Each is linked with NOVA2 in more than 6 cancer types. Because this analysis shows association rather than direction, both NOVA2-to-partner and partner-to-NOVA2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NOVA2 versus EDNRB in CCRCC, with a Pearson correlation of 0.71.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOVA2→partner) and Y-score (partner→NOVA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	EDNRB →	+1.406	+0.536	<.001	<.001	3	7
CCRCC	CD34 →	+0.952	+0.520	<.001	<.001	3	7
CCRCC	RGS5 →	+1.562	+0.540	<.001	<.001	3	6
CCRCC	PBX1 →	+1.061	+0.398	<.001	<.001	3	6
BRCA	SLC6A4 →	+0.795	+0.340	.002	<.001	3	6
UCEC	RHOJ →	+0.997	+0.373	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,224 associations by consensus.

NOVA2 vs EDNRB — CCRCC

Explore this scatter interactively →