NOVA2

Across TCGA patient cohorts, NOVA2 mutation is significantly associated with the RNA expression of many other genes, with 305 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOVA2-associated genes across cancer lineages are TRAJ12, RPS10P21, and RN7SL198P. Each is linked with NOVA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NOVA2-to-partner and partner-to-NOVA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ12 grouped by NOVA2-low versus NOVA2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOVA2→partner) and Y-score (partner→NOVA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRAJ12 →	+1.179	+3.818	.001	.009	3	3
LUSC	RPS10P21 →	+0.412	+4.984	<.001	.009	3	3
SKCM	RN7SL198P →	+0.164	+3.717	<.001	.005	3	2
LIHC	LINC02135 →	+0.018	+5.544	.003	.004	3	2
BLCA	SNORA10B →	+0.457	+4.642	.001	.004	3	2
UCEC	TRAJ48 →	+0.714	+2.560	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 305 associations by consensus.

TRAJ12 by NOVA2 expression — COAD

Explore this box plot interactively →