NOVA2

Across TCGA patient cohorts, NOVA2 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOVA2-associated genes across cancer lineages are ERK2, eEF2, and ETS-1. Each is linked with NOVA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOVA2-to-partner and partner-to-NOVA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by NOVA2-low versus NOVA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOVA2→partner) and Y-score (partner→NOVA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.324	+3.169	.002	.019	3	2
UCEC	eEF2 →	+0.390	+3.169	.047	.020	3	1
UCEC	ETS-1 →	+0.448	+3.000	.010	.036	3	1
UCEC	MSH2 →	-0.389	-3.169	.002	.020	3	1
UCEC	Myosin-IIa →	+0.269	+3.177	.008	.010	3	1
UCEC	p53 →	-0.444	-3.000	.036	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ERK2 by NOVA2 expression — UCEC

Explore this box plot interactively →