NOVA2

Across TCGA cell cohorts, NOVA2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NOVA2-associated genes across cancer lineages are TAAR1, ADGRA1, and TLE7. Each is linked with NOVA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOVA2-to-partner and partner-to-NOVA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAAR1 grouped by NOVA2-low versus NOVA2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOVA2→partner) and Y-score (partner→NOVA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TAAR1 →	+0.021	+4.922	<.001	.009	3	1
BLOOD_Leukemia	ADGRA1 →	+0.006	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.046	+5.969	<.001	.001	3	1
STOMACH	C1orf146 →	+0.036	+4.432	<.001	.003	3	1
STOMACH	TRIM49C →	+0.023	+4.794	<.001	.001	3	1
STOMACH	KRTAP4-11 →	+0.015	+4.285	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

TAAR1 by NOVA2 expression — BLOOD_Leukemia

Explore this box plot interactively →