NOVA1

Across TCGA pan-cancer cohorts, NOVA1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of NOVA1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NOVA1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types NOVA1 is over-expressed in tumor, although a few such as HNSC and PDAC show the opposite, repressed pattern.

HNSC, PDAC, and LSCC are the cancer types where NOVA1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NOVA1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	−1.312	<.001	8	view →
PDAC	All	All	−1.241	.015	4	view →
LSCC	Female	All	−0.600	<.001	4	view →
LUAD	Female	III,IV	−0.585	.002	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

NOVA1–HNSC

Open the HNSC breakdown →