Across TCGA patient cohorts, NOTO mutation is significantly associated with the RNA expression of many other genes, with 118 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOTO-associated genes across cancer lineages are RNU6-591P, MIR3118-3, and MIR3118-2. Each is linked with NOTO in more than 1 cancer types. Because this analysis shows association rather than direction, both NOTO-to-partner and partner-to-NOTO results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTO→partner) and Y-score (partner→NOTO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-591P →	+0.373	+7.741	<.001	.009	3	2
BRCA	MIR3118-3 →	+0.558	+8.471	<.001	.005	3	1
BRCA	MIR3118-2 →	+0.559	+9.057	<.001	.003	3	1
UCEC	YTHDF3-AS1 →	+0.977	+3.223	<.001	.009	3	1
UCEC	SNRPGP17 →	+0.407	+3.101	<.001	.001	3	1
UCEC	MIR7976 →	+0.607	+2.868	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 118 associations by consensus.

Exploration

NOTO survival (RNA) · tumor vs normal (RNA) · all NOTO data types