Across TCGA patient cohorts, NOTCH4 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,867 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible NOTCH4-associated proteins across cancer lineages are LAMA4, NID2, and NID1. Each is linked with NOTCH4 in more than 9 cancer types. Because this analysis shows association rather than direction, both NOTCH4-to-partner and partner-to-NOTCH4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTCH4→partner) and Y-score (partner→NOTCH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LAMA4 →	+0.800	+0.989	<.001	<.001	3	10
OV	NID2 →	+0.672	+0.820	<.001	<.001	3	9
GBM	NID1 →	+0.596	+0.597	<.001	<.001	3	8
OV	OLFML3 →	+0.843	+0.657	<.001	.002	3	8
OV	PCOLCE →	+0.783	+0.646	<.001	.001	3	8
CCRCC	VWA1 →	+0.608	+1.135	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,867 associations by consensus.

Exploration

NOTCH4 survival (RNA) · tumor vs normal (RNA) · all NOTCH4 data types