Across TCGA patient cohorts, NOTCH4 protein abundance is significantly associated with the RNA expression of many other genes, with 2,423 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NOTCH4-associated genes across cancer lineages are BCL6B, CDH5, and CHAC2. Each is linked with NOTCH4 in more than 2 cancer types. Because this analysis shows association rather than direction, both NOTCH4-to-partner and partner-to-NOTCH4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTCH4→partner) and Y-score (partner→NOTCH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	BCL6B →	+0.721	+0.590	<.001	.002	3	3
CCRCC	CDH5 →	+0.928	+0.965	.008	<.001	3	3
LSCC	CHAC2 →	-0.768	-0.413	.001	.007	3	2
LSCC	RUVBL1 →	-0.796	-0.762	.002	<.001	3	2
CCRCC	LINC02412 →	+0.350	+0.680	.005	.005	3	2
PDAC	HTATSF1 →	-0.579	-0.382	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,423 associations by consensus.

Exploration

NOTCH4 survival (RNA) · tumor vs normal (RNA) · all NOTCH4 data types