Across TCGA patient cohorts, NOTCH4 mutation is significantly associated with the RNA expression of many other genes, with 6,131 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOTCH4-associated genes across cancer lineages are FMO4, MND1, and ZWINT. Each is linked with NOTCH4 in more than 4 cancer types. Because this analysis shows association rather than direction, both NOTCH4-to-partner and partner-to-NOTCH4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTCH4→partner) and Y-score (partner→NOTCH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FMO4 →	-0.578	-2.654	<.001	<.001	3	5
STAD	MND1 →	+0.762	+2.717	<.001	.003	3	5
UCEC	ZWINT →	+0.670	+1.898	<.001	<.001	3	5
CESC	PPAT →	+0.690	+3.184	.002	.009	2	5
BRCA	RNA5SP477 →	+0.598	+3.599	.001	.009	3	4
STAD	ALDOA →	+0.546	+3.359	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,131 associations by consensus.

Exploration

NOTCH4 survival (RNA) · tumor vs normal (RNA) · all NOTCH4 data types