Across TCGA cell cohorts, NOTCH4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,198 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NOTCH4-associated GO terms across cancer lineages are Phospholipase C-activating G protein-coupled receptor signaling pathway, Positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled, and Protein localization to site of double-strand break. Each is linked with NOTCH4 in more than 7 cancer types. Because this analysis shows association rather than direction, both NOTCH4-to-partner and partner-to-NOTCH4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTCH4→partner) and Y-score (partner→NOTCH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Phospholipase C-activating G protein-coupled receptor signaling pathway →	-0.067	-1.270	<.001	<.001	3	8
KIDNEY	Positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled →	+0.111	+0.259	<.001	.005	3	8
BLOOD_Myeloma	Protein localization to site of double-strand break →	+0.096	+0.664	.003	.003	3	8
SKIN	Negative regulation of retinoic acid receptor signaling pathway →	+0.140	+0.582	.004	.002	3	7
LUNG_SCLC	Positive regulation of termination of RNA polymerase II transcription →	+0.121	+1.290	.001	<.001	2	8
BREAST	Regulation of mucus secretion →	-1.131	-0.835	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,198 associations by consensus.

Exploration

NOTCH4 survival (RNA) · tumor vs normal (RNA) · all NOTCH4 data types