Across TCGA cell cohorts, NOTCH4 mutation is significantly associated with the RNA expression of many other genes, with 628 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NOTCH4-associated genes across cancer lineages are CFAP43, ARHGAP19, and SCT. Each is linked with NOTCH4 in more than 2 cancer types. Because this analysis shows association rather than direction, both NOTCH4-to-partner and partner-to-NOTCH4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTCH4→partner) and Y-score (partner→NOTCH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CFAP43 →	+0.450	+2.628	<.001	.002	3	3
LARGE_INTESTINE	ARHGAP19 →	+0.621	+2.628	.004	.002	3	3
SOFT_TISSUE	SCT →	+1.587	+3.635	<.001	.007	3	2
URINARY_TRACT	FHL5 →	+0.010	+4.087	<.001	.009	3	2
LARGE_INTESTINE	KCND1 →	+0.649	+3.321	<.001	.003	3	2
LARGE_INTESTINE	BCL7A →	+0.786	+2.714	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 628 associations by consensus.

Exploration

NOTCH4 survival (RNA) · tumor vs normal (RNA) · all NOTCH4 data types