NOTCH1

Across TCGA pan-cancer cohorts, NOTCH1 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated NOTCH1 data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher NOTCH1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated NOTCH1 expression acts as an unfavorable survival marker, although some lineages such as LGG show a favorable association.

PAAD, KIRC, and UCEC are the cancer types where NOTCH1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	DFS	Median	All	0.116	0.509	.002	12	view →
KIRC	DFS	Median	III,IV	0.203	0.744	.025	12	view →
UCEC	OS	Median	IV	0.066	0.755	<.001	12	view →
SKCM	OS	Median	III,IV	0.245	0.721	.018	9	view →
OV	DFS	Median	III,IV	0.215	0.532	.029	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
BLCA	DFS	Median	IV	0.207	0.477	.022	6	view →
LGG	OS	Median	All	0.818	0.430	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

NOTCH1–PAAD (DFS)

Open the PAAD breakdown →