NOTCH1

Across TCGA pan-cancer cohorts, NOTCH1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NOTCH1 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher NOTCH1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NOTCH1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where NOTCH1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.215	0.500	.003	37	view →
HNSC	OS	Tertile	All	0.856	0.669	.016	10	view →
LUAD	OS	Quartile	III,IV	0.407	0.876	.022	6	view →
LSCC	DFS	Median	All	0.885	0.976	.012	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NOTCH1–PDAC (DFS)

Open the PDAC breakdown →