NOTCH1

Across TCGA pan-cancer cohorts, NOTCH1 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of NOTCH1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where NOTCH1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types NOTCH1 is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

LUAD, PDAC, and LSCC are the cancer types where NOTCH1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NOTCH1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	−0.501	<.001	8	view →
PDAC	Female	All	+0.813	.001	4	view →
LSCC	All	III,IV	−0.162	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

NOTCH1–LUAD

Open the LUAD breakdown →