NOTCH1

Across TCGA patient cohorts, NOTCH1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,740 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NOTCH1-associated proteins across cancer lineages are HID1, ARFGAP3, and ARFGEF2. Each is linked with NOTCH1 in more than 4 cancer types. Because this analysis shows association rather than direction, both NOTCH1-to-partner and partner-to-NOTCH1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NOTCH1 versus HID1 in LUAD, with a Pearson correlation of -0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTCH1→partner) and Y-score (partner→NOTCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HID1 →	-0.512	-0.621	<.001	<.001	3	5
LSCC	ARFGAP3 →	-0.270	-0.858	.001	<.001	3	4
BRCA	ARFGEF2 →	-0.282	-0.593	<.001	<.001	3	4
LSCC	DNAJC1 →	-0.439	-0.604	<.001	.002	3	4
LSCC	GBF1_S662 →	-0.450	-0.907	<.001	<.001	3	4
LSCC	GBF1 →	-0.268	-0.910	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,740 associations by consensus.

NOTCH1 vs HID1 — LUAD

Explore this scatter interactively →