NOTCH1

Across TCGA patient cohorts, NOTCH1 protein abundance is significantly associated with the RNA expression of many other genes, with 6,614 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NOTCH1-associated genes across cancer lineages are NRARP, AQP9, and ELAPOR1. Each is linked with NOTCH1 in more than 3 cancer types. Because this analysis shows association rather than direction, both NOTCH1-to-partner and partner-to-NOTCH1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NOTCH1 versus NRARP in LSCC, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTCH1→partner) and Y-score (partner→NOTCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NRARP →	+1.355	+0.352	<.001	<.001	3	4
BRCA	AQP9 →	+1.473	+0.596	<.001	<.001	3	3
UCEC	ELAPOR1 →	-1.920	-0.243	.001	.004	3	3
BRCA	BCL2A1 →	+1.084	+0.394	.003	.002	3	3
GBM	SPATA18 →	-1.363	-0.416	<.001	<.001	3	3
PDAC	CD300E →	+0.974	+0.621	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,614 associations by consensus.

NOTCH1 vs NRARP — LSCC

Explore this scatter interactively →