NOTCH1

Across TCGA cell cohorts, NOTCH1 protein abundance is significantly associated with the RNA expression of many other genes, with 4,016 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NOTCH1-associated genes across cancer lineages are ZNF367, MYBL2, and KIF22. Each is linked with NOTCH1 in more than 4 cancer types. Because this analysis shows association rather than direction, both NOTCH1-to-partner and partner-to-NOTCH1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NOTCH1 versus ZNF367 in BLOOD_Leukemia, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTCH1→partner) and Y-score (partner→NOTCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZNF367 →	+0.902	+0.657	<.001	<.001	3	5
BLOOD_Leukemia	MYBL2 →	+0.917	+0.517	<.001	<.001	3	5
BLOOD_Leukemia	KIF22 →	+0.737	+0.608	<.001	<.001	3	5
BREAST	NDUFS2 →	-0.692	-0.746	<.001	.003	3	4
BLOOD_Leukemia	JADE3 →	+0.796	+0.453	.002	.002	3	4
BLOOD_Myeloma	NUMA1 →	+1.069	+1.015	.005	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,016 associations by consensus.

NOTCH1 vs ZNF367 — BLOOD_Leukemia

Explore this scatter interactively →