NOTCH1

Across TCGA cell cohorts, NOTCH1 protein abundance is significantly associated with the go_rna of many other GO terms, with 2,291 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NOTCH1-associated GO terms across cancer lineages are Regulation of pH, Cell cycle DNA replication, and Negative regulation of sodium ion transport. Each is linked with NOTCH1 in more than 5 cancer types. Because this analysis shows association rather than direction, both NOTCH1-to-partner and partner-to-NOTCH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of pH grouped by NOTCH1-low versus NOTCH1-high in LARGE_INTESTINE.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTCH1→partner) and Y-score (partner→NOTCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of pH →	-0.062	-1.063	.001	<.001	3	5
BLOOD_Leukemia	Cell cycle DNA replication →	+0.062	+0.503	.004	<.001	2	6
BREAST	Negative regulation of sodium ion transport →	-0.112	-0.504	.004	.006	3	4
BREAST	Regulation of centrosome duplication →	+0.070	+0.608	.003	.002	2	5
BLOOD_Leukemia	Replication fork processing →	+0.086	+0.576	<.001	.001	3	4
BLOOD_Leukemia	Spindle localization →	+0.102	+0.763	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,291 associations by consensus.

Regulation of pH by NOTCH1 expression — LARGE_INTESTINE

Explore this box plot interactively →