NOTCH1

Across TCGA cell cohorts, NOTCH1 mutation is significantly associated with the RNA expression of many other genes, with 3,096 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NOTCH1-associated genes across cancer lineages are SMCHD1, ZC3H14, and SEC24B. Each is linked with NOTCH1 in more than 3 cancer types. Because this analysis shows association rather than direction, both NOTCH1-to-partner and partner-to-NOTCH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMCHD1 grouped by NOTCH1-low versus NOTCH1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOTCH1→partner) and Y-score (partner→NOTCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SMCHD1 →	+0.830	+3.584	<.001	<.001	3	4
LARGE_INTESTINE	ZC3H14 →	+0.510	+2.700	<.001	.001	3	4
LARGE_INTESTINE	SEC24B →	+0.631	+2.130	<.001	<.001	3	4
LARGE_INTESTINE	SIRT1 →	+0.673	+2.628	<.001	<.001	3	4
BLOOD_Leukemia	GABPB2 →	+0.611	+2.518	.001	.003	3	4
BREAST	PDCL2 →	+0.164	+3.624	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,096 associations by consensus.

SMCHD1 by NOTCH1 expression — LARGE_INTESTINE

Explore this box plot interactively →