NOSIP

Across TCGA patient cohorts, NOSIP protein abundance is significantly associated with the RNA expression of many other genes, with 9,866 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NOSIP-associated genes across cancer lineages are VRK1, IRF3, and SAE1. Each is linked with NOSIP in more than 5 cancer types. Because this analysis shows association rather than direction, both NOSIP-to-partner and partner-to-NOSIP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NOSIP versus VRK1 in LSCC, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOSIP→partner) and Y-score (partner→NOSIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	VRK1 →	+0.654	+0.246	<.001	<.001	3	6
PDAC	IRF3 →	+0.424	+0.325	<.001	<.001	3	6
BRCA	SAE1 →	+0.431	+0.363	<.001	<.001	3	6
BRCA	PIH1D1 →	+0.756	+0.512	<.001	<.001	3	6
OV	ATAD2 →	+0.912	+0.286	.002	.008	3	5
OV	ZNF845 →	+0.667	+0.307	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,866 associations by consensus.

NOSIP vs VRK1 — LSCC

Explore this scatter interactively →