NOSIP

Across TCGA cell cohorts, NOSIP RNA expression is significantly associated with the go_rna of many other GO terms, with 2,883 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible NOSIP-associated GO terms across cancer lineages are Regulation of protein sumoylation, Protein-DNA complex organization, and U2-type prespliceosome assembly. Each is linked with NOSIP in more than 10 cancer types. Because this analysis shows association rather than direction, both NOSIP-to-partner and partner-to-NOSIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein sumoylation grouped by NOSIP-low versus NOSIP-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NOSIP→partner) and Y-score (partner→NOSIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of protein sumoylation →	+0.095	+0.573	<.001	<.001	3	11
SOFT_TISSUE	Protein-DNA complex organization →	+0.070	+0.714	<.001	<.001	3	11
STOMACH	U2-type prespliceosome assembly →	+0.106	+0.922	.001	<.001	3	10
SKIN	Spliceosomal snRNP assembly →	+0.095	+0.844	<.001	<.001	3	10
STOMACH	Spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) →	+0.103	+0.774	.001	<.001	3	10
BREAST	Response to mitochondrial depolarisation →	+0.083	+0.685	<.001	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,883 associations by consensus.

Regulation of protein sumoylation by NOSIP expression — LARGE_INTESTINE

Explore this box plot interactively →