NOSIP

Across TCGA cell cohorts, NOSIP mutation is significantly associated with the drug of many other genes, with 42 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NOSIP-associated genes across cancer lineages are Camptothecin, AZD7969, and I-BRD9. Each is linked with NOSIP in more than 1 cancer types. Because this analysis shows association rather than direction, both NOSIP-to-partner and partner-to-NOSIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Camptothecin grouped by NOSIP-low versus NOSIP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOSIP→partner) and Y-score (partner→NOSIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Camptothecin →	+0.617	+2.868	.026	.022	3	1
LARGE_INTESTINE	AZD7969 →	+0.465	+2.649	.042	.046	3	1
LARGE_INTESTINE	I-BRD9 →	+0.544	+2.649	.004	.046	3	1
LARGE_INTESTINE	N29087-69-1 →	+0.369	+2.655	.025	.044	3	1
LARGE_INTESTINE	Zibotentan →	+0.223	+2.874	.020	.021	3	1
LARGE_INTESTINE	NSC-207895 →	+0.586	+3.008	.003	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Camptothecin by NOSIP expression — LARGE_INTESTINE

Explore this box plot interactively →