Across TCGA pan-cancer cohorts, NOS1AP RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated NOS1AP data layer compared with 4 for mutation status and 7 for mass-spec protein.
The strongest signal is observed in breast invasive carcinoma (BRCA), where higher NOS1AP RNA is associated with better overall survival. In most high-consensus cancer types, elevated NOS1AP expression acts as an unfavorable survival marker, although some lineages such as BRCA and KIRC show a favorable association.
BRCA, KIRC, and READ are the cancer types where NOS1AP RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.