NOS1

Across TCGA pan-cancer cohorts, NOS1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NOS1 data layer compared with 22 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher NOS1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NOS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where NOS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.899	0.528	.023	5	view →
PDAC	OS	Quartile	III,IV	0.328	1.000	.024	5	view →
HNSC	DFS	Tertile	III,IV	1.000	0.939	.042	4	view →
LSCC	DFS	Quartile	III,IV	1.000	0.373	.029	4	view →
CCRCC	OS	Quartile	All	1.000	0.774	.037	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NOS1–LUAD (OS)

Open the LUAD breakdown →