NOS1

Across TCGA patient cohorts, NOS1 mutation is significantly associated with the RNA expression of many other genes, with 7,068 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOS1-associated genes across cancer lineages are GOT1, FEN1, and EXO1. Each is linked with NOS1 in more than 5 cancer types. Because this analysis shows association rather than direction, both NOS1-to-partner and partner-to-NOS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOT1 grouped by NOS1-low versus NOS1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOS1→partner) and Y-score (partner→NOS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	GOT1 →	+0.444	+3.459	.006	.004	3	6
LUAD	FEN1 →	+0.627	+2.333	<.001	<.001	3	6
LUAD	EXO1 →	+0.876	+2.035	<.001	<.001	3	6
LUAD	NCAPG →	+0.777	+2.608	<.001	<.001	3	6
UCEC	MRPL37 →	+0.346	+1.495	<.001	.001	3	6
LUAD	TAF5 →	+0.299	+1.727	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,068 associations by consensus.

GOT1 by NOS1 expression — STAD

Explore this box plot interactively →