NOS1

Across TCGA patient cohorts, NOS1 mutation is significantly associated with the total protein of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOS1-associated genes across cancer lineages are eIF4E, c-Kit, and Cyclin-B1. Each is linked with NOS1 in more than 6 cancer types. Because this analysis shows association rather than direction, both NOS1-to-partner and partner-to-NOS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by NOS1-low versus NOS1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOS1→partner) and Y-score (partner→NOS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	eIF4E →	+0.208	+2.828	.008	.033	3	7
COAD	c-Kit →	-0.462	-2.000	.009	.027	3	4
UCEC	Cyclin-B1 →	+0.502	+2.502	.001	.001	3	4
UCEC	mTOR_pS2448 →	-0.122	-1.571	.003	.015	3	4
UCEC	p38-MAPK_pT180_Y182 →	-0.437	-1.584	<.001	.002	3	4
STAD	FASN →	+0.463	+3.337	.010	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

eIF4E by NOS1 expression — STAD

Explore this box plot interactively →