NOS1

Across TCGA cell cohorts, NOS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,706 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible NOS1-associated GO terms across cancer lineages are Negative regulation of calcium ion transport into cytosol, Regulation of cytoplasmic translation, and Proton motive force-driven ATP synthesis. Each is linked with NOS1 in more than 8 cancer types. Because this analysis shows association rather than direction, both NOS1-to-partner and partner-to-NOS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion transport into cytosol grouped by NOS1-low versus NOS1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NOS1→partner) and Y-score (partner→NOS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of calcium ion transport into cytosol →	-0.254	-2.525	<.001	<.001	3	9
OESOPHAGUS	Regulation of cytoplasmic translation →	+0.079	+1.125	<.001	.007	3	6
UPPER_AERODIGESTIVE_TRACT	Proton motive force-driven ATP synthesis →	+0.092	+0.583	<.001	.007	3	6
SOFT_TISSUE	Nuclear export →	+0.054	+1.638	.003	.003	3	6
SOFT_TISSUE	Nuclear transport →	+0.050	+1.627	.001	.003	3	6
SOFT_TISSUE	DNA-templated transcription initiation →	+0.053	+2.132	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,706 associations by consensus.

Negative regulation of calcium ion transport into cytosol by NOS1 expression — BONE

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