NOS1

Across TCGA cell cohorts, NOS1 mutation is significantly associated with the RNA expression of many other genes, with 598 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NOS1-associated genes across cancer lineages are TMA16, C7orf33, and RESP18. Each is linked with NOS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NOS1-to-partner and partner-to-NOS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMA16 grouped by NOS1-low versus NOS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOS1→partner) and Y-score (partner→NOS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMA16 →	+0.483	+2.364	.002	<.001	3	3
LUNG_NSCLC_LUSC	C7orf33 →	+0.348	+3.584	<.001	.003	3	2
LUNG_SCLC	RESP18 →	+0.111	+2.483	.001	.003	3	2
BLOOD_Leukemia	NPFFR1 →	+0.010	+2.622	<.001	.003	3	2
BLOOD_Leukemia	C22orf39 →	+0.591	+3.199	.001	.007	3	2
BLOOD_Leukemia	OC90 →	+0.004	+2.979	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 598 associations by consensus.

TMA16 by NOS1 expression — LARGE_INTESTINE

Explore this box plot interactively →