NORAD

Across TCGA pan-cancer cohorts, NORAD RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of NORAD’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where NORAD RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NORAD is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

KIRP, COAD, and LIHC are the cancer types where NORAD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NORAD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	All	+0.526	<.001	11	view →
COAD	Male	All	+0.921	<.001	9	view →
LIHC	Female	II,III,IV	+0.913	<.001	9	view →
THCA	Male	All	−0.554	<.001	7	view →
HNSC	All	All	+0.377	.004	7	view →
UCEC	All	All	−0.985	<.001	6	view →
CHOL	Male	All	+1.729	<.001	5	view →
STAD	All	II,III,IV	+0.814	<.001	5	view →
PAAD	All	All	+0.477	.013	2	view →
ESCA	All	All	+0.743	.017	1	view →
READ	All	All	+0.661	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

NORAD–KIRP

Open the KIRP breakdown →