NOP58

Across TCGA pan-cancer cohorts, NOP58 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NOP58 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NOP58 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NOP58 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where NOP58 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.427	0.776	<.001	72	view →
HNSC	DFS	Median	III,IV	0.291	1.000	.001	64	view →
LSCC	DFS	Quartile	II,III,IV	0.926	0.514	.014	15	view →
GBM	OS	Tertile	All	0.703	0.432	.003	14	view →
PDAC	DFS	Quartile	II,III,IV	0.257	0.519	.009	10	view →
UCEC	DFS	Median	II,III,IV	0.534	0.867	.044	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NOP58–CCRCC (DFS)

Open the CCRCC breakdown →