NOP58

Across TCGA patient cohorts, NOP58 protein abundance is significantly associated with the RNA expression of many other genes, with 19,695 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NOP58-associated genes across cancer lineages are GAS5, EXOSC5, and ZFAS1. Each is linked with NOP58 in more than 7 cancer types. Because this analysis shows association rather than direction, both NOP58-to-partner and partner-to-NOP58 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NOP58 versus GAS5 in OV, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOP58→partner) and Y-score (partner→NOP58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GAS5 →	+0.818	+0.381	<.001	<.001	3	8
HNSC	EXOSC5 →	+1.008	+0.147	<.001	<.001	3	8
BRCA	ZFAS1 →	+0.609	+0.290	<.001	.001	3	7
BRCA	PVT1 →	+0.716	+0.305	<.001	<.001	3	7
OV	EIF3E →	+0.872	+0.482	<.001	<.001	3	7
HNSC	RPS19 →	+1.341	+0.168	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,695 associations by consensus.

NOP58 vs GAS5 — OV

Explore this scatter interactively →