NOP58

Across TCGA patient cohorts, NOP58 mutation is significantly associated with the RNA expression of many other genes, with 3,154 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOP58-associated genes across cancer lineages are MIR4643, RNU6-796P, and RN7SKP213. Each is linked with NOP58 in more than 2 cancer types. Because this analysis shows association rather than direction, both NOP58-to-partner and partner-to-NOP58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4643 grouped by NOP58-low versus NOP58-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOP58→partner) and Y-score (partner→NOP58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR4643 →	+0.175	+3.897	<.001	.009	3	2
CESC	RNU6-796P →	+0.393	+3.381	.001	.003	3	2
CESC	RN7SKP213 →	+0.105	+3.595	<.001	.005	3	2
LUSC	AQP7P4 →	+0.050	+6.081	<.001	.002	3	2
LUSC	RNA5SP212 →	+0.454	+5.211	<.001	.007	3	2
BRCA	GCSHP2 →	+0.113	+5.122	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,154 associations by consensus.

MIR4643 by NOP58 expression — SKCM

Explore this box plot interactively →