NOP58

Across TCGA patient cohorts, NOP58 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOP58-associated genes across cancer lineages are ASNS, EGFR_pY1068, and eIF4E. Each is linked with NOP58 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOP58-to-partner and partner-to-NOP58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by NOP58-low versus NOP58-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOP58→partner) and Y-score (partner→NOP58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.431	+2.584	.001	.010	3	2
UCEC	EGFR_pY1068 →	-0.239	-3.459	.011	.005	3	1
UCEC	eIF4E →	+0.194	+2.662	.014	<.001	3	1
UCEC	eIF4G →	+0.273	+2.321	.018	.033	3	1
UCEC	FASN →	+0.461	+2.222	.001	.010	3	1
UCEC	FoxM1 →	+0.252	+2.469	.009	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ASNS by NOP58 expression — UCEC

Explore this box plot interactively →