NOP58

Across TCGA cell cohorts, NOP58 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NOP58-associated genes across cancer lineages are NAA11, ADAMTS4, and REG1B. Each is linked with NOP58 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOP58-to-partner and partner-to-NOP58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NAA11 grouped by NOP58-low versus NOP58-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOP58→partner) and Y-score (partner→NOP58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NAA11 →	+0.323	+3.694	.003	.001	3	1
LARGE_INTESTINE	ADAMTS4 →	+0.180	+2.889	<.001	.005	3	1
LARGE_INTESTINE	REG1B →	+1.989	+2.933	<.001	.003	3	1
LARGE_INTESTINE	OR10W1 →	+0.008	+3.240	.001	.004	3	1
LARGE_INTESTINE	MYH13 →	+0.433	+2.791	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

NAA11 by NOP58 expression — LARGE_INTESTINE

Explore this box plot interactively →