NOP56

Across TCGA patient cohorts, NOP56 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOP56-associated genes across cancer lineages are ATM, 14-3-3_beta, and FASN. Each is linked with NOP56 in more than 2 cancer types. Because this analysis shows association rather than direction, both NOP56-to-partner and partner-to-NOP56 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NOP56-low versus NOP56-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOP56→partner) and Y-score (partner→NOP56) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.444	-2.415	.003	.003	3	3
UCEC	14-3-3_beta →	-0.081	-1.780	.016	.024	3	2
UCEC	FASN →	+0.298	+1.765	.023	.013	3	2
UCEC	mTOR_pS2448 →	-0.162	-3.893	.001	<.001	3	2
UCEC	Notch1 →	+0.156	+2.013	<.001	.004	3	2
UCEC	PCNA →	+0.236	+2.502	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ATM by NOP56 expression — UCEC

Explore this box plot interactively →