NOP56

Across TCGA cell cohorts, NOP56 mutation is significantly associated with the drug of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NOP56-associated genes across cancer lineages are LCL161, RVX-208, and AZD5991. Each is linked with NOP56 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOP56-to-partner and partner-to-NOP56 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCL161 grouped by NOP56-low versus NOP56-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOP56→partner) and Y-score (partner→NOP56) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LCL161 →	+0.377	+2.646	.020	.047	3	1
LARGE_INTESTINE	RVX-208 →	+0.344	+2.646	.026	.047	3	1
LARGE_INTESTINE	AZD5991 →	+1.309	+2.649	<.001	.046	3	1
LARGE_INTESTINE	NSC-207895 →	+0.440	+2.786	.043	.037	3	1
LARGE_INTESTINE	Pelitinib →	+0.694	+2.786	.032	.037	3	1
LARGE_INTESTINE	Masitinib →	+0.507	+2.652	.017	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

LCL161 by NOP56 expression — LARGE_INTESTINE

Explore this box plot interactively →