NOP53

Across TCGA pan-cancer cohorts, NOP53 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated NOP53 data layer compared with 29 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NOP53 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NOP53 expression acts as an unfavorable survival marker.

HNSC, THCA, and STAD are the cancer types where NOP53 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.156	0.743	.001	42	view →
THCA	DFS	Median	All	0.027	0.945	<.001	24	view →
STAD	OS	Median	All	0.096	0.688	<.001	24	view →
KIRC	OS	Median	All	0.181	0.805	.002	21	view →
BLCA	DFS	Median	III,IV	0.097	0.572	<.001	21	view →
LUAD	DFS	Median	All	0.207	0.666	.003	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SKCM	DFS	Median	III,IV	0.046	0.648	<.001	6	view →
COAD	DFS	Median	All	0.107	0.556	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

NOP53–HNSC (OS)

Open the HNSC breakdown →