NOP53

Across TCGA pan-cancer cohorts, NOP53 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NOP53 data layer compared with 29 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NOP53 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NOP53 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

HNSC, LSCC, and LUAD are the cancer types where NOP53 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.779	0.949	<.001	43	view →
LSCC	DFS	Median	II,III,IV	0.855	0.505	.004	24	view →
LUAD	DFS	Median	All	0.605	1.000	<.001	23	view →
PDAC	DFS	Median	III,IV	0.887	0.418	.001	12	view →
CCRCC	DFS	Quartile	III,IV	0.377	0.746	.010	9	view →
UCEC	DFS	Tertile	All	1.000	0.909	.037	4	view →
GBM	DFS	Quartile	All	0.803	0.395	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NOP53–HNSC (OS)

Open the HNSC breakdown →