NOP53

Across TCGA patient cohorts, NOP53 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOP53-associated genes across cancer lineages are mTOR, ACC_pS79, and JNK2. Each is linked with NOP53 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOP53-to-partner and partner-to-NOP53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR grouped by NOP53-low versus NOP53-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOP53→partner) and Y-score (partner→NOP53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR →	-0.259	-2.321	.001	.035	3	2
UCEC	ACC_pS79 →	-0.382	-2.990	.028	.036	3	1
UCEC	JNK2 →	+0.378	+2.834	<.001	.034	3	1
UCEC	MEK1 →	+0.539	+3.459	.003	.005	3	1
UCEC	MSH2 →	-0.324	-2.321	.005	.035	3	1
UCEC	mTOR_pS2448 →	-0.172	-3.150	.021	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

mTOR by NOP53 expression — UCEC

Explore this box plot interactively →