NOP53-AS1

Across TCGA pan-cancer cohorts, NOP53-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated NOP53-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NOP53-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated NOP53-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UVM show a favorable association.

KIRC, ACC, and UVM are the cancer types where NOP53-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.733	0.513	<.001	89	view →
ACC	DFS	Tertile	All	0.369	0.788	<.001	68	view →
UVM	OS	Quartile	All	0.883	0.550	.003	64	view →
KIRP	OS	Quartile	III,IV	0.293	0.706	.003	62	view →
COAD	DFS	Quartile	All	0.621	0.854	.012	41	view →
CESC	OS	Median	All	0.838	0.908	.012	30	view →
GBM	OS	Tertile	All	0.522	0.327	.008	27	view →
MESO	DFS	Quartile	II,III,IV	0.198	0.430	.019	24	view →
THYM	DFS	Median	III,IV	1.000	0.479	.018	20	view →
UCEC	OS	Median	III,IV	0.692	0.475	.022	20	view →
ESCA	DFS	Tertile	IV	0.221	0.692	.024	12	view →
READ	DFS	Median	III,IV	0.869	0.631	.004	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

NOP53-AS1–KIRC (OS)

Open the KIRC breakdown →