NOP2

Across TCGA pan-cancer cohorts, NOP2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NOP2 data layer compared with 28 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NOP2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NOP2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where NOP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.301	0.789	<.001	47	view →
HNSC	DFS	Quartile	IV	0.594	0.950	.002	13	view →
LSCC	DFS	Quartile	II,III,IV	0.886	0.513	.015	9	view →
PDAC	OS	Tertile	All	0.466	0.662	.034	4	view →
LUAD	OS	Median	II,III,IV	0.449	0.893	.023	3	view →
GBM	OS	Median	All	0.649	0.391	.014	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NOP2–CCRCC (DFS)

Open the CCRCC breakdown →