NOP2

Across TCGA cell cohorts, NOP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,532 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NOP2-associated GO terms across cancer lineages are rRNA 5'-end processing, Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and rRNA metabolic process. Each is linked with NOP2 in more than 18 cancer types. Because this analysis shows association rather than direction, both NOP2-to-partner and partner-to-NOP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA 5'-end processing grouped by NOP2-low versus NOP2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NOP2→partner) and Y-score (partner→NOP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	rRNA 5'-end processing →	+0.183	+1.221	<.001	<.001	3	19
LIVER	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.183	+1.221	<.001	<.001	3	19
OESOPHAGUS	rRNA metabolic process →	+0.123	+0.832	<.001	<.001	3	18
LUNG_SCLC	Ribosomal small subunit biogenesis →	+0.113	+1.302	<.001	<.001	3	18
LARGE_INTESTINE	Transcription initiation at RNA polymerase I promoter →	+0.133	+0.935	<.001	<.001	3	18
OESOPHAGUS	rRNA processing →	+0.127	+0.738	<.001	.002	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,532 associations by consensus.

rRNA 5'-end processing by NOP2 expression — LIVER

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