NOP2

Across TCGA cell cohorts, NOP2 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NOP2-associated genes across cancer lineages are NLRP5, ACTL9, and IL5RA. Each is linked with NOP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOP2-to-partner and partner-to-NOP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NLRP5 grouped by NOP2-low versus NOP2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOP2→partner) and Y-score (partner→NOP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	NLRP5 →	+0.006	+4.017	<.001	.007	3	1
OESOPHAGUS	ACTL9 →	+0.022	+4.392	<.001	.003	3	1
OESOPHAGUS	IL5RA →	+0.065	+4.857	<.001	<.001	3	1
SOFT_TISSUE	OR4X2 →	+0.032	+5.369	<.001	.004	3	1
LARGE_INTESTINE	KCNG2 →	+0.092	+3.243	<.001	.006	3	1
LARGE_INTESTINE	PFN3 →	+0.091	+3.204	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

NLRP5 by NOP2 expression — OESOPHAGUS

Explore this box plot interactively →