NOP14

Across TCGA pan-cancer cohorts, NOP14 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated NOP14 data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher NOP14 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NOP14 expression acts as an unfavorable survival marker.

UVM, SCLC, and ESCA are the cancer types where NOP14 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.220	0.917	<.001	18	view →
SCLC	DFS	Median	II,III,IV	0.137	0.602	.008	18	view →
ESCA	DFS	Median	II,III,IV	0.173	0.525	.017	15	view →
SKCM	OS	Median	III,IV	0.224	0.708	<.001	15	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
KIRP	OS	Median	All	0.599	0.903	.025	6	view →
LGG	DFS	Median	All	0.110	0.833	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
BLCA	OS	Median	IV	0.192	0.603	.008	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

NOP14–UVM (OS)

Open the UVM breakdown →