NOP14

Across TCGA pan-cancer cohorts, NOP14 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NOP14 data layer compared with 24 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NOP14 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NOP14 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where NOP14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.202	0.764	<.001	66	view →
HNSC	DFS	Quartile	All	0.215	1.000	.005	37	view →
LUAD	OS	Quartile	III,IV	0.861	0.194	.026	13	view →
LSCC	OS	Tertile	II,III,IV	0.884	0.578	.025	5	view →
UCEC	DFS	Quartile	III,IV	1.000	0.300	.020	4	view →
PDAC	DFS	Tertile	IV	0.741	0.203	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NOP14–CCRCC (DFS)

Open the CCRCC breakdown →