NOP14

Across TCGA patient cohorts, NOP14 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. COAD shows the largest number of these associations.

The most reproducible NOP14-associated genes across cancer lineages are ATM, 4E-BP1, and EGFR_pY1068. Each is linked with NOP14 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOP14-to-partner and partner-to-NOP14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NOP14-low versus NOP14-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOP14→partner) and Y-score (partner→NOP14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.703	-3.161	<.001	.019	3	2
COAD	4E-BP1 →	+0.299	+3.000	.005	.035	3	2
UCEC	EGFR_pY1068 →	-0.214	-2.115	.020	.017	3	2
COAD	GSK-3a-b_pS21_S9 →	-0.477	-2.974	.013	.035	3	1
COAD	JNK_pT183_Y185 →	-0.341	-3.000	.007	.035	3	1
COAD	PDCD4 →	-0.606	-3.161	.003	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ATM by NOP14 expression — COAD

Explore this box plot interactively →