NOP14

Across TCGA cell cohorts, NOP14 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,272 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NOP14-associated GO terms across cancer lineages are Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), Ribosome biogenesis, and Ribosomal small subunit biogenesis. Each is linked with NOP14 in more than 17 cancer types. Because this analysis shows association rather than direction, both NOP14-to-partner and partner-to-NOP14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by NOP14-low versus NOP14-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NOP14→partner) and Y-score (partner→NOP14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.121	+1.001	<.001	<.001	3	18
BONE	Ribosome biogenesis →	+0.154	+1.204	<.001	<.001	3	17
BONE	Ribosomal small subunit biogenesis →	+0.152	+1.302	<.001	<.001	3	17
BONE	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.159	+1.156	<.001	<.001	3	16
BONE	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.160	+1.046	<.001	<.001	3	16
BONE	Maturation of SSU-rRNA →	+0.144	+1.089	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,272 associations by consensus.

Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by NOP14 expression — BONE

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