NONO

Across TCGA patient cohorts, NONO protein abundance is significantly associated with the RNA expression of many other genes, with 19,452 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NONO-associated genes across cancer lineages are LAS1L, DKC1, and SNRNP200. Each is linked with NONO in more than 8 cancer types. Because this analysis shows association rather than direction, both NONO-to-partner and partner-to-NONO results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NONO versus LAS1L in LSCC, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NONO→partner) and Y-score (partner→NONO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LAS1L →	+0.496	+0.154	<.001	<.001	3	9
LSCC	DKC1 →	+0.733	+0.193	<.001	<.001	3	8
UCEC	SNRNP200 →	+0.839	+0.231	<.001	<.001	3	8
COAD	TAF1 →	+0.577	+0.150	<.001	<.001	3	8
LSCC	PATZ1 →	+0.638	+0.167	<.001	<.001	3	7
UCEC	PCIF1 →	+0.611	+0.143	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,452 associations by consensus.

NONO vs LAS1L — LSCC

Explore this scatter interactively →