NONO

Across TCGA patient cohorts, NONO mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NONO-associated genes across cancer lineages are eIF4E, p53, and Paxillin. Each is linked with NONO in more than 1 cancer types. Because this analysis shows association rather than direction, both NONO-to-partner and partner-to-NONO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by NONO-low versus NONO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NONO→partner) and Y-score (partner→NONO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.139	+2.428	.023	.001	3	2
UCEC	p53 →	-0.295	-2.115	.008	.016	3	2
UCEC	Paxillin →	+0.216	+1.775	.004	.007	3	2
UCEC	Tuberin_pT1462 →	+0.168	+1.280	.012	.049	3	2
UCEC	C-Raf →	+0.122	+1.807	.003	.024	3	2
UCEC	14-3-3_beta →	-0.095	-2.143	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

eIF4E by NONO expression — UCEC

Explore this box plot interactively →